Primary Tissue Pipeline
Methods and Services
- Project support
- Contact with clinics
- Patient recruitment and selection of suitable bioprobes
- Assistance in obtaining ethics approval
- Setting up project-specific logistics for sample collection
- Providing vital bioprobes and clinical data
- Contact with clinics
- Patient recruitment and selection of suitable bioprobes
- Assistance in obtaining ethics approval
- Setting up project-specific logistics for sample collection
- Providing vital bioprobes and clinical data
Responsible Persons
Karin Schmelz
Booking
IHMValidation: Assessment of Integrative Structure Models Deposited to the Protein Data Bank
Arthur O Zalevsky , Brinda Vallat , Benjamin M Webb , Hongsuda Tangmunarunkit , Monica R Sekharan , Aref Shafaeibejestan , Sai Ganesan , Jared Sagendorf , Cy M Jeffries , Jill Trewhella , Andrea Graziadei , Juan Antonio Vizcaíno , Alexander Leitner , Juri Rappsilber , Ezra Peisach , Justin W Flatt , Jasmine Y Young , Kartik Majila , Shruthi Viswanath , Carl Kesselman , Jeffrey C Hoch , Genji Kurisu , Kyle L Morris , Sameer Velankar , Helen M Berman , Stephen K Burley , Andrej Sali
Journal of Molecular Biology
18.12.2025
Modeling immune lineage co-development in human pluripotent stem cell-derived liver organoids
Milad Rezvani, Susanna Quach, Kyle Lewis, Norikazu Saiki, Chuqing Xue, Masaki Kimura, Kentaro Iwasawa, Julian Weihs, Tahlil Elzobair, Hasan Al Reza, Yuqi Cai, RanRan Zhang, Yuka Milton, Praneet Chaturvedi, Konrad Thorner, Ramesh C. Nayak, Jorge Munera, Phillip Kramer, Brian R. Davis, Appakalai N. Balamurugan, Takanori Takebe
Journal of Hepatology
17.12.2025
Patient-derived organoids to study glycosylation dynamics during gastric disease
Santos-Ferreira L, Martins ÁM, Duarte HO, Moia E, Costa AF, de Ru AH, Faria-Ramos I, Matos R, Barros R, Cavadas B, Silva M, Pedrosa S, Batista DA, Gomes J, Borén T, Sousa F, Casanova-Gonçalves F, Barbosa J, Magalhães A, Gomes C, Santos-Sousa H, Bartfeld S, Wuhrer M, de Haan N, Carneiro F, Reis CA, Pinto F
Cell Reports
25.11.2025
Butyrophilin 3A/2A1-independent activation of human Vγ9Vδ2 γδ T cells by bacteria
Daniel Gombert, Jara Simeonov, Katharina Klein, Sophie Agaugué, Alexander Scheffold, Dieter Kabelitz, Christian Peters
PNAS Nexus
13.11.2025
Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid-derived monolayers compared to HeLa cells
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld
FEBS Letters
13.10.2025
Rewired type I IFN signaling is linked to age-dependent differences in COVID-19
Petrov L, Brumhard S, Wisniewski S, Georg P, Hillus D, Hiller A, Astaburuaga-García R, Blüthgen N, Wyler E, Vogt K, Dey HP, von Stillfried S, Iwert C, Bülow RD, Märkl B, Maas L, Langner C, Meyer T, Loske J, Eils R, Lehmann I, Ondruschka B, Ralser M, Trimpert J, Boor P, Bedoui S, Meisel C, Mall MA, Corman VM, Sander LE, Röhmel J, Sawitzki B
Cell Reports. Medicine
19.08.2025
Aging and Viral Evolution Impair Immunity Against Dominant Pan-Coronavirus-Reactive T Cell Epitope
Loyal L, Jürchott K, Reimer U, Meyer-Arndt L, Henze L, Mages N, Kostrzanowski J, Reus B, Mangold M, Kruse B, Dingeldey M, Sawitzki B, Michel J, Grossegesse M, Schnatbaum K, Wenschuh H, Nitsche A, Lachmann N, Timmermann B, Giesecke-Thiel C, Braun J, Kern F, Thiel A
European Journal of Immunology
28.07.2025
An NADH-controlled gatekeeper of ATP synthase
Fabian Schildhauer , Petra S J Ryl , Simon M Lauer , Swantje Lenz , Ayşe Berçin Barlas , Vasileios R Ouzounidis , Kate Jeffrey , Daniel-Cosmin Marcu , Francis J O'Reilly , Andrea Graziadei , Marchel Stuiver , Kita Schmidt , Helge Ewers , Christian M T Spahn , Ezgi Karaca , Karl Emanuel Busch , Dhanya Cheerambathur , David Schwefel , Juri Rappsilber
Molecular Cell
03.07.2025
Prosit-XL: enhanced cross-linked peptide identification by fragment intensity prediction to study protein interactions and structures
Mostafa Kalhor, Cemil Can Saylan, Mario Picciani, Lutz Fischer, Falk Boudewijn Schimweg, Joel Lapin, Juri Rappsilber, Mathias Wilhelm
Nature Communications
01.07.2025
A Roadmap for Improving Reliability and Data Sharing in Crosslinking Mass Spectrometry
Juri Rappsilber, James Bruce, Colin Combe, Stephen D Fried, Andrea Graziadei, Albert J R Heck, Claudio Iacobucci, Alexander Leitner, Karl Mechtler, Petr Novak, Francis O'Reilly, David C Schriemer, Andrea Sinz, Florian Stengel, Konstantinos Thalassinos
Molecular & Cellular Proteomics
26.06.2025
Frequency of synaptic antigen-specific CD4+ T cells in dementia is age-dependent but not correlated with cognitive impairment
Julius Hoffmann, Marie-Luise Machule, Jakob Kreye, Laura Stöffler, Péter Körtvelyessy, Maria Buthut, Rosa Rößling, Petra Bacher, Alexander Scheffold, Harald Prüss
Immunity and Ageing
19.06.2025
Hybrid immunity-based induction of durable pan-endemic-coronavirus immunity in the elderly
Lucie Loyal, Julian Braun, Ulf Reimer,Lil Meyer-Arndt,Larissa Henze, Beate Kruse, Manuela Dingeldey, Maike Mangold, Janina Behrens, Pinkus Tober Lau, Janine Michel, Marica Grossegesse, Karsten Schnatbaum, Holger Wenschuh, Wibke Johannis, Veronica Di Cristanziano, Andreas Nitsche, Florian Klein, Leif-Erik Sander and Andreas Thiel
Cell Reports
25.02.2025
The cellular and molecular cardiac tissue responses in human inflammatory cardiomyopathies after SARS-CoV-2 infection and COVID-19 vaccination
Maatz H, Lindberg EL, Adami E, López-Anguita N, Perdomo-Sabogal A, Cocera Ortega L, Patone G, Reichart D, Myronova A, Schmidt S, Elsanhoury A, Klein O, Kühl U, Wyler E, Landthaler M, Yousefian S, Haas S, Kurth F, Teichmann SA, Oudit GY, Milting H, Noseda M, Seidman JG, Seidman CE, Heidecker B, Sander LE, Sawitzki B, Klingel K, Doeblin P, Kelle S, Van Linthout S, Hubner N, Tschöpe C
Nature Cardiovascular Research
24.02.2025
Survival of Human Bone Marrow Plasma Cells In Vitro Depends on the Support of the Stromal Cells, PI3K, and Canonical NF-kappaB Signaling
Zehra Uyar-Aydin, Shirin Kadler, Roland Lauster, Sina Bartfeld, Mark Rosowski
European Journal of Immuology
08.01.2025
The role of allergen-specific regulatory T cells in the control of allergic disease
Athanasios Stoumpos, Guido Heine, Carina Saggau, Alexander Scheffold
Current Opinion in Immunology
06.12.2024
Transcriptomic and de novo proteomic analyses of organotypic entorhino-hippocampal tissue cultures reveal changes in metabolic and signaling regulators in TTX-induced synaptic plasticity
Maximilian Lenz, Paul Turko, Pia Kruse, Amelie Eichler, Zhuo Angel Chen, Juri Rappsilber, Imre Vida & Andreas Vlachos
Molecular Brain
07.11.2024
ATP-Triggered Fe(CN)2CO Synthon Transfer from the Maturase HypCD to the Active Site of Apo-[NiFe]-Hydrogenase
Anna Kwiatkowski, Giorgio Caserta, Anne-Christine Schulz, Stefan Frielingsdorf, Vladimir Pelmenschikov, Kilian Weisser, Adam Belsom, Juri Rappsilber, Ilya Sergueev, Christian Limberg, Maria-Andrea Mroginski, Ingo Zebger, Oliver Lenz
Journal of the Amrerican Chemical Society
03.11.2024
3R centres contributions to change animal experimentation : A field report from Charité 3R, the 3R centre of a medical faculty
Ida Retter, Laura Behm, Lisa Grohmann, Karin Schmelz, Jennifer Rosowski and Stefan Hippenstiel
EMBO Reports
13.09.2024
Modelling protein complexes with crosslinking mass spectrometry and deep learning
Kolja Stahl, Robert Warneke, Lorenz Demann, Rica Bremenkamp, Björn Hormes, Oliver Brock, Jörg Stülke, Juri Rappsilber
Nature Communications
09.09.2024
Infection of human organoids supports an intestinal niche for Chlamydia trachomatis
Pargev Hovhannisyan, Kathrin Stelzner, Markus Keicher, Kerstin Paprotka, Mastura Neyazi, Mindaugas Pauzuolis, Waled Mohammed Ali, Karthika Rajeeve, Sina Bartfeld, Thomas Rudel
PLoS Pathogens
22.08.2024
Rescuing error control in crosslinking mass spectrometry
Lutz Fischer, Juri Rappsilber
Molecular Systems Biology
02.08.2024
CD4+CD8αlow T Cell Clonal Expansion Dependent on Costimulation in Patients With Rheumatoid Arthritis
Felix Beck, Phuong Nguyen, Anne Hoffmann, Lucie Loyal, Andreas Thiel, Marc Melzer, Hannah Apel, Matthias Pierer, Marco Krasselt, Olga Seifert, Anne-Marie Glimm, Tobias Hagemann, Kathrin Rothe, Ulf Wagner
Arthritis & Rheumatology
25.07.2024
SARS-CoV-2 tropism to intestinal but not gastric epithelial cells is defined by limited ACE2 expression
Paužuolis, M., Fatykhova, D., Zühlke, B., Schwecke, T., Neyazi, M., Samperio-Ventayol, P., Aguilar, C., Schlegel, N., Dökel, S., Ralser, M., Hocke, A., Krempl, C., & Bartfeld, S.
Stem cell reports
14.05.2024
Tolerance induction through early feeding to prevent food allergy in infants and children with sensitization against food allergens (TIFFANI): rationale, study design, and methods of a randomized controlled trial
Birgit Kalb, Lara Meixner, Stephanie Heller, Sabine Dölle-Bierke, Stephanie Roll, Tatjana Tissen-Diabaté, Susanne Lau, Sofia Forslund, Ingo Marenholz, Young-Ae Lee, Andreas Thiel, Magda Babina, Jörg Scheffel, Margitta Worm & Kirsten Beyer
Trials
19.04.2024
Structure of the native γ-tubulin ring complex capping spindle microtubules
Tom Dendooven, Stanislau Yatskevich, Alister Burt, Zhuo A. Chen, Dom Bellini, Juri Rappsilber, John V. Kilmartin & David Barford
Nature Structural & Molecular Biology
12.04.2024
Comparable CD8+ T-cell responses to SARS-CoV-2 vaccination in single-cell transcriptomics of recently allogeneic transplanted patients and healthy individuals
Eva Tranter, Marco Frentsch, Marie Luise Hütter-Krönke, Giang Lam Vuong, David Busch, Lucie Loyal, Larissa Henze, Stanislav Rosnev, Igor-Wolfgang Blau, Andreas Thiel, Dieter Beule, Lars Bullinger, Benedikt Obermayer, Il-Kang Na
Journal of Medical Virology
22.03.2024
Organoids as a tool to study the impact of heterogeneity in gastrointestinal epithelium on host-pathogen interactions
Mindaugas Paužuolis, Pilar Samperio Ventayol, Mastura Neyazi, Sina Bartfeld
Clinical and Experimental Immunology
20.01.2024
Gen- und Zelltherapie 2.023. Forschung, klinische Anwendung und Gesellschaft
Boris Fehse, Hannah Schickl, Sina Bartfeld, Martin Zenke
Springer
30.12.2023
Associations of myeloid cells with cellular and humoral responses following vaccinations in patients with neuroimmunological diseases
Meng Wang, Adeline Dehlinger, Camila Fernández Zapata,
Maya Golan, GerardinaGallaccio, Leif E. Sander, Stephan Schlickeiser,
Desiree Kunkel, Tanja Schmitz-Hübsch, Birgit Sawitzki,
Arnon Karni, Julian Braun, Lucie Loyal, Andreas Thiel,
Judith Bellmann-Strobl, Friedemann Paul, Lil Meyer-Arndt &
Chotima Böttcher
Nature Communications
25.11.2023
A dive into the unknome
Juri Rappsilber
Trends in Genetics
13.11.2023
Cleavable Cross-Linkers Redefined by a Novel MS3-Trigger Algorithm
Lars Kolbowski, Lutz Fischer, and Juri Rappsilber
Analytical Chemistry
24.10.2023
Toward a 3D Printed Perfusable Islet Embedding Structure: Technical Notes and Preliminary Results
Eriselda Keshi, Peter Tang, Tobias Lam, Simon Moosburner, Luna Haderer, Anja Reutzel-Selke, Lutz Kloke, Johann Pratschke, Igor Maximilian Sauer and Karl Herbert Hillebrandt
Tissue Engineering Part C: Methods
11.10.2023
Harvest of adherend cells from Cytodex® 1 beads
David König, Kim Kremser, Sina Bartfeld, Shirin Kadler
protocols.io parts of Springer Nature
12.09.2023
Haunting innate immune memories of COVID-19
Birgit Sawitzki
Cell
31.08.2023
Long-term symptom severity and clinical biomarkers in post-COVID-19/chronic fatigue syndrome: results from a prospective observational cohort
Franziska Legler, Lil Meyer-Arndt, Lukas Mödl, Claudia Kedor, Helma Freitag, Elisa Stein, Uta Hoppmann, Rebekka Rust, Kirsten Wittke, Nadja Siebert, Janina Behrens, Andreas Thiel, Frank Konietschke, Friedemann Paul, Carmen Scheibenbogen, Judith Bellmann-Strobl
eClinicalMedicine
18.08.2023
Light-Induced Orthogonal Fragmentation of Crosslinked Peptides
Lars Kolbowski, Adam Belsom, Ana M Pérez-López, Tony Ly, Juri Rappsilber
Journal of the American Chemical Society Au
17.08.2023
SARS-CoV-2 mRNA vaccinations fail to elicit humoral and cellular immune responses in patients with multiple sclerosis receiving fingolimod
Lil Meyer-Arndt, Julian Braun, Florent Fauchere Kanika Vanshylla , Lucie Loyal, Larissa Henze, Beate Kruse, Manuela Dingeldey, Karsten Jürchott, Maike Mangold, Ardit Maraj, Andre Braginets, Chotima Böttcher , Andreas Nitsche, Kathrin de la Rosa, Christoph Ratswohl, Birgit Sawitzki, Pavlo Holenya, Ulf Reimer, Leif E Sander, Florian Klein, Friedemann Paul, Judith Bellmann-Strobl, Andreas Thiel, Claudia Giesecke-Thiel
BMJ nerology, Neurosurgery & Psychiatry
14.07.2023
Ex vivo infection model for Francisella using human lung tissue
Kristin Köppen, Diana Fatykhova , Gudrun Holland, Jessica Rauch, Dennis Tappe, Mareike Graff, Kerstin Rydzewski, Andreas C Hocke, Stefan Hippenstiel, Klaus Heuner
Frontiers in Cellular and Infection Microbiology
10.07.2023
The unremarkable alveolar epithelial glycocalyx: a thorium dioxide-based electron microscopic comparison after heparinase or pneumolysin treatment
Sara Timm, Marie Lettau, Jan Hegermann, Maria Linda Rocha, Sarah Weidenfeld, Diana Fatykhova, Birgitt Gutbier, Geraldine Nouailles, Elena Lopez-Rodriguez, Andreas Hocke, Stefan Hippenstiel, Martin Witzenrath, Wolfgang M Kuebler, Matthias Ochs
Histochemistry and Cell Biology
29.06.2023
Data-driven analysis of chemicals, proteins and pathways associated with peanut allergy: from molecular networking to biological interpretation
Emmanuel Kemmler, Julian Braun, Florent Fauchère, Sabine Dölle-Bierke, Kirsten
Beyer, Robert Preissner, Margitta Worm, Priyanka Banerjeea
Food Science and Human Wellness
01.06.2023
Protein structure dynamics by crosslinking mass spectrometry
Zhuo Angel Chen, Juri Rappsilber
Current Opinion in Structural Biology
25.04.2023
RECAST: Study protocol for an observational study for the understanding of the increased REsilience of Children compared to Adults in SARS-CoV-2 infecTion
Sebastian Stricker, Niklas Ziegahn, Martin Karsten, Thomas Boeckel, Heike Stich-Boeckel, Jakob Maske, Evelyn Rugo, Anita Balazs, Pamela Millar Büchner, Chantip Dang-Heine, Valentin Schriever, Roland Eils, Irina Lehmann, Leif E Sander, Markus Ralser, Victor M Corman, Marcus A Mall, Birgit Sawitzki, Jobst Roehmel
BMJ Open
17.04.2023
Protein structure prediction with in-cell photo-crosslinking mass spectrometry and deep learning
Kolja Stahl, Andrea Graziadei, Therese Dau, Oliver Brock, Juri Rappsilber
Nature Biotechnology
20.03.2023
Bioactive photocrosslinkable resin solely based on refined decellularized small intestine submucosa for vat photopolymerization of in vitro tissue mimics
Laura Elomaa, Lorenz Gerbeth, Ahed Almalla, Nora Fribiczer, Assal Daneshgar, Peter Tang, Karl Hillebrandt, Sebastian Seiffert, Igor M. Sauer, Britta Siegmund, Marie Weinhart
Additive Manufacturing
25.02.2023
Dual-Bioorthogonal Catalysis by a Palladium Peptide Complex
Ana M. Pérez-López, Adam Belsom, Linus Fiedler, Xiaoyi Xin, and Juri Rappsilber
Journal of Medicinal Chemistry
23.02.2023
Protein complexes in cells by AI-assisted structural proteomics
Francis J O'Reilly, Andrea Graziadei, Christian Forbrig, Rica Bremenkamp, Kristine Charles, Swantje Lenz, Christoph Elfmann, Lutz Fischer, Jörg Stülke, Juri Rappsilber
Molecular Systems Biology
23.02.2023
ISSCR Education Committee syllabus and learning guide for enhancing stem cell literacy
Julie R Perlin, William J Anderson, Sina Bartfeld, Anna Couturier, Yvanka de Soysa, R Scott Hawley, Ping Hu, Yuin-Han Loh, Lolitika Mandal, Zubin Master, Alysson R Muotri, Eugenia Piddini, Jose M Polo, Esteban O Mazzoni
Stem Cell Reports
14.02.2023
Structural mechanism of CRL4‐instructed STAT2 degradation via a novel cytomegaloviral DCAF receptor
Vu Thuy Khanh Le-Trilling, Sofia Banchenko, Darius Paydar, Pia Madeleine Leipe, Lukas Binting, Simon Lauer, Andrea Graziadei, Robin Klingen, Christine Gotthold, Jörg Bürger, Thilo Bracht, Barbara Sitek, Robert Jan Lebbink, Anna Malyshkina, Thorsten Mielke, Juri Rappsilber, Christian MT Spahn, Sebastian Voigt, Mirko Trilling, David Schwefel
The EMBO Journal
10.02.2023
Primary ChAdOx1 vaccination does not reactivate pre-existing, cross-reactive immunity
Larissa Henze, Julian Braun, Lil Meyer-Arndt, Karsten Jürchott, Maike Schlotz, Janine Michel, Marica Grossegesse, Maike Mangold, Manuela Dingeldey, Beate Kruse, Pavlo Holenya, Norbert Mages, Ulf Reimer, Maren Eckey, Karsten Schnatbaum, Holger Wenschuh, Bernd Timmermann, Florian Klein, Andreas Nitsche, Claudia Giesecke-Thiel, Lucie Loyal, Andreas Thiel
Frontiers in Immunology
31.01.2023
Single-cell gene regulatory network prediction by explainable AI
Philipp Keyl, Philip Bischoff, Gabriel Dernbach, Michael Bockmayr, Rebecca Fritz, David Horst, Nils Blüthgen, Grégoire Montavon, Klaus-Robert Müller, Frederick Klauschen
Nucleic Acids Research
11.01.2023
State-of-the-art analytical methods of viral infections in human lung organoids
Morris Baumgardt, Maren Hülsemann, Anna Löwa, Diana Fatykhova, Karen Hoffmann, Mirjana Kessler, Maren Mieth, Katharina Hellwig, Doris Frey, Alina Langenhagen, Anne Voss, Benedikt Obermayer, Emanuel Wyler, Simon Dökel, Achim D Gruber, Ulf Tölch, Stefan Hippenstiel, Andreas C Hocke, Katja Hönzke
PLoS One
20.12.2022
Engineering Vascular Self-Assembly by Controlled 3D-Printed Cell Placement
Isabel Orellano, Alexander Thomas, Aaron Herrera, Erik Brauer, Dag Wulsten, Ansgar Petersen, Lutz Kloke, Georg N. Duda
Advanced Functional Materials
02.11.2022
Helicobacter pylori shows tropism to gastric differentiated pit cells dependent on urea chemotaxis
Carmen Aguilar, Mindaugas Pauzuolis, Malvika Pompaiah, Ehsan Vafadarnejad, Panagiota Arampatzi, Mara Fischer, Dominik Narres, Mastura Neyazi, Özge Kayisoglu, Thomas Sell, Nils Blüthgen, Markus Morkel, Armin Wiegering, Christoph-Thomas Germer, Stefan Kircher, Andreas Rosenwald, Antoine-Emmanuel Saliba, Sina Bartfeld
Nature Communications
05.10.2022
Editorial: 3D tissue models in infection research
Vera Kozjak-Pavlovic, Wenxia Song, Sina Bartfeld, Marco Metzger
Frontiers in Cellular and Infection Microbiology
22.07.2022
Understudied proteins: opportunities and challenges for functional proteomics
Georg Kustatscher, Tom Collins, Anne-Claude Gingras, Tiannan Guo, Henning Hermjakob, Trey Ideker, Kathryn S Lilley, Emma Lundberg, Edward M Marcott, Markus Ralser, Juri Rappsilber
Nature methods
09.05.2022
Immune cell-stem cell interactions in regeneration and repair: who's calling the shots?
Pilar Samperio Ventayol, Sina Bartfeld
Development
03.05.2022
Cutting Edge: Serum but Not Mucosal Antibody Responses Are Associated with Pre-Existing SARS-CoV-2 Spike Cross-Reactive CD4+ T Cells following BNT162b2 Vaccination in the Elderly.
Lil Meyer-Arndt, Tatjana Schwarz, Lucie Loyal, Larissa Henze, Beate Kruse, Manuela Dingeldey, Kübrah Gürcan, Zehra Uyar-Aydin, Marcel A Müller, Christian Drosten, Friedemann Paul, Leif-Erik Sander, Ilja Demuth, Roland Lauster, Claudia Giesecke-Thiel, Julian Braun, Victor M Corman, Andreas Thiel
The Journal of Immunology
01.03.2022
VolumetricOR: A New Approach to Simulate Surgical Interventions in Virtual Reality for Training and Education
Queisner M, Pogorzhelskiy M, Remde C, Pratschke J, Sauer IM.
Surgical Innovation
09.02.2022
Complement activation induces excessive T cell cytotoxicity in severe COVID-19
Georg, Philipp, Astaburuaga-García, Rosario, Bonaguro, Lorenzo, Brumhard, Sophia, Michalick, Laura, Lippert, Lena J., Kostevc, Tomislav, Gäbel, Christiane, Schneider, Maria, Streitz, Mathias, Demichev, Vadim, Gemünd, Ioanna, Barone, Matthias, Tober-Lau, Pinkus, Helbig, Elisa T., Hillus, David, Petrov, Lev, Stein, Julia, Dey, Hannah-Philine, Paclik, Daniela, Iwert, Christina, Mülleder, Michael, Aulakh, Simran Kaur, Djudjaj, Sonja, Bülow, Roman D., Mei, Henrik E., Schulz, Axel R., Thiel, Andreas, Hippenstiel, Stefan, Saliba, Antoine-Emmanuel, Eils, Roland, Lehmann, Irina, Mall, Marcus A., Stricker, Sebastian, Röhmel, Jobst, Corman, Victor M., Beule, Dieter, Wyler, Emanuel, Landthaler, Markus, Obermayer, Benedikt, von Stillfried, Saskia, Boor, Peter, Demir, Münevver, Wesselmann, Hans, Suttorp, Norbert, Uhrig, Alexander, Müller-Redetzky, Holger, Nattermann, Jacob, Kuebler, Wolfgang M., Meisel, Christian, Ralser, Markus, Schultze, Joachim L., Aschenbrenner, Anna C., Thibeault, Charlotte, Kurth, Florian, Sander, Leif E., Blüthgen, Nils, Sawitzki, Birgit
Cell
03.02.2022
Cross-reactive CD4+ T cells enhance SARS-CoV-2 immune responses upon infection ans vaccination
Lucie Loyal, Julian Braun, Larissa Henze, Beate Kruse, Manuela Dingeldey, Ulf Reimer, Florian Kern, Tatjana Schwarz, Maike Mangold, Clara Unger, Friederike Dörfler, Shirin Kadler, Jennifer Rosowski, Kübrah Gürcan, Zehra Uyar-Aydin, Marco Frentsch, Florian Kurth, Karsten Schnatbaum, Maren Eckey, Stefan Hippenstiel, Andreas Hocke, Marcel A Müller, Birgit Sawitzki, Stefan Miltenyi, Friedemann Paul, Marcus A Mall, Holger Wenschuh, Sebastian Voigt, Christian Drosten, Roland Lauster, Nils Lachman, Leif-Erik Sander, Victor M Corman, Jobst Röhmel, Lil Meyer-Arndt, Andreas Thiel, Claudia Giesecke-Thiel
Science
08.10.2021
Pilot investigation on the dose-dependent impact of irradiation on primary human alveolar osteoblasts in vitro
Anna-Klara Amler, Domenic Schlauch, Selin Tüzüner, Alexander Thomas, Norbert Neckel, Ingeborg Tinhofer, Max Heiland, Roland Lauster, Lutz Kloke, Carmen Stromberger, Susanne Nahles
Scientific Reports
06.10.2021
Adaptive Images: Challenges for Visual Studies and Media Theory
Bruhn M, Friedrich K, Queisner M.
International Journal for Digital Art History
01.10.2021
An Individual Patient's "Body" on Chips-How Organismoid Theory Can Translate Into Your Personal Precision Therapy Approach
Uwe Marx, Enrico Accastelli, Rhiannon David, Hendrik Erfurth, Leopold Koenig, Roland Lauster, Anja Patricia Ramme, Petra Reinke, Hans-Dieter Volk, Annika Winter, Eva-Maria Dehne
Frontiers in Medicine
13.09.2021
Bioprinted Multi-Cell Type Lung Model for the Study of Viral Inhibitors
Johanna Berg, Zia Weber, Mona Fechler-Bitteti, Andreas C Hocke, Stefan Hippenstiel, Laura Elomaa, Marie Weinhart, Jens Kurreck
Viruses
11.08.2021
A Reproducible Bioprinted 3D Tumor Model Serves as a Preselection Tool for CAR T Cell Therapy Optimization
Grunewald Laura, Lam Tobias, Andersch Lena, Klaus Anika, Schwiebert Silke, Winkler Annika, Gauert Anton, Heeren-Hagemann Anja I., Astrahantseff Kathy, Klironomos Filippos, Thomas Alexander, Deubzer Hedwig E., Henssen Anton G., Eggert Angelika, Schulte Johannes H., Anders Kathleen, Kloke Lutz, Künkele Annette
Frontiers in Immunology
29.06.2021
BACH1 Binding Links the Genetic Risk for Severe Periodontitis with ST8SIA1
Chopra A, Mueller R, Weiner J 3rd, Rosowski J, Dommisch H, Grohmann E, Schaefer AS
Journal of Dental Research
23.06.2021
3D bioprinting of tissue-specific osteoblasts and endothelial cells to model the human jawbone
Anna-Klara Amler, Alexander Thomas, Selin Tüzüner, Tobias Lam, Michel-Andreas Geiger, Anna-Elisabeth Kreuder, Chris Palmer, Susanne Nahles, Roland Lauster, Lutz Kloke
Scientific Reports
01.03.2021
Gastrointestinal epithelial innate immunity-regionalization and organoids as new model
Özge Kayisoglu, Nicolas Schlegel, Sina Bartfeld
Journal of Molecular Medicine
04.02.2021
Realizing the potential of organoids - an interview with Hans Clevers
Sina Bartfeld
Journal of Molecular Medicine
19.01.2021
Vascular bioprinting with enzymatically degradable bioinks via multi-material projection-based stereolithography
Alexander Thomas, Isabel Orellano, Tobias Lam, Benjamin Noichl, Michel-Andreas Geiger, Anna-Klara Amler, Anna-Elisabeth Kreuder, Christopher Palmer, Georg Duda, Roland Lauster, Lutz Kloke
Acta Biomaterialia
24.09.2020
Metal-Specific Biomaterial Accumulation in Human Peri-Implant Bone and Bone Marrow
Janosch Schoon, Bernhard Hesse, Anastasia Rakow, Melanie J. Ort, Adrien Lagrange, Dorit Jacobi, Annika Winter, Katrin Huesker, Simon Reinke, Marine Cotte, Remi Tucoulou, Uwe Marx, Carsten Perka, Georg N. Duda and Sven Geissler
Advanced Science
03.08.2020
SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19
Julian Braun, Lucie Loyal, Marco Frentsch, Daniel Wendisch, Philipp Georg, Florian Kurth, Stefan Hippenstiel, Manuela Dingeldey, Beate Kruse, Florent Fauchere, Emre Baysal, Maike Mangold, Larissa Henze, Roland Lauster, Marcus A Mall, Kirsten Beyer, Jobst Röhmel, Sebastian Voigt, Jürgen Schmitz, Stefan Miltenyi, Ilja Demuth, Marcel A Müller, Andreas Hocke, Martin Witzenrath, Norbert Suttorp, Florian Kern, Ulf Reimer, Holger Wenschuh, Christian Drosten, Victor M Corman, Claudia Giesecke-Thiel, Leif-Erik Sander, Andreas Thiel
Nature
29.07.2020
Effects of 5-aza-2´-deoxycytidine on primary human chondrocytes from osteoarthritic patients
Shirin Kadler, Özlem Vural, Jennifer Rosowski, Luzia Reiners-Schramm, Roland Lauster, Mark Rosowski
PLOS ONE
23.06.2020